CPAA conducts systematic scientific studies of cancer related issues,
such as risk factors, epidemiology and psychosocial effects on cancer
patients their near and dear ones and caregivers. The data is presented
in peer- reviewed national and international journals, conferences,
seminars and workshops. Translational research to identify
susceptibility biomarkers is the other area of interest.
The focus of the Research team is translational research in the
realm of identification of 'Predictive Markers' in Oral
Cancer' and 'Cervical Cancer', and to study the psychosocial effects
of cancer on patients and family members.
A. Translational Research Studies:
Project 1: Identification of 'Predictive Biomarkers' and Virtual
Screening of 'Small Drug- like Molecules' targeted to Oral Cancer .
Dr. Dhananjaya Saranath, Dr. Sultan Pradhan, Hetal Damani
Oral cancer is a high incidence cancer in India,
constituting 26% of the global oral cancer burden. The major risk
factors are tobacco/areca nut, alcohol and high risk Human Papilloma
Virus, contribute 90% of attributable risk to the cancer. However
about 5-10% individuals with high risk life style develop oral
cancer. Thus individual genomic variants could be used to identify
individuals who will develop oral cancer. The team is investigated
genomic variants represented as single nucleotide polymorphisms in
long term tobacco habitues with and without oral cancer.
Project 2: Development of HPV Screening Protocol as a part of
CPAA's Early Detection Programme
Dr. Dhananjaya Saranath, Neeta More
High risk Human Papilloma Virus (HR-HPV)detection protocol
using State-of-the-art molecular technology for detecting and typing
of HR-HPV PCR and nucleotide sequencing to indicate risk of cervical
cancer. About 3,250 women in cancer screening camps were screened.
The data defined 4.4% women HPV positive with 18% positive for HR-HPV
including HPV 16/18 and 3% positive for low risk HPVs. A follow up
in the HPV positive women is under progress.
Psychosocial Projects: To study the psychosocial effect of cancer
on patients and family members
The ability to cope with hematological cancers in Pediatric
patients: a cross sectional study. Data collection is in
process. Dr. Dhananjaya Saranath, Dr. Veena Shukla
Post-traumatic growth and quality of life in breast cancer
patients and their caregivers. Dr. Dhananjaya Saranath, Dr.
Perceived risk, anxiety and alexithymia in siblings of breast
cancer patients. Manuscript is in review with the Editor,
members and reviewers, Psycho-oncology Journal. Dr. Veena Shukla,
Dr. Dhananjaya Saranath
Perceived social support and mental adjustment in breast cancer
patients. Manuscript is in review with the Editor, members and
reviewers. Dr. Veena Shukla, Dr. Dhananjaya Saranath
Knowledge of, attitudes towards cervical cancer screening among
women in Mumbai, India. Dr. Dhananjaya Saranath, Dr. Veena
Shukla, Ms Masara Shameem
Association between distress and post traumatic growth among
adolescent cancer patients. Dr. Veena Shukla, Dr. Dhananjaya
Post treatment- follow up care of cancer patients and
Caregivers. Dr. Veena Shukla, Dr. Dhananjaya Saranath, Manju
Quality of life and perceived social support, in caregivers of
cancer patients. Dr. Veena Shukla, Vinaya Chacko, Mallika
Narayan, Halima Aurangabadkar, Dr. Dhananjaya Saranath
Challenges in India about Breast Cancer & Breast Reconstruction.
Dr. Bijoy Methil, Consultant Plastic Surgeon, Jaslok Hospital &
Saifee Hospital, Dr. Shubha Maudgal - Poster Presentation